Table 2.
SNPs Significantly Associated with Disc Degeneration.
| Gene | COMT | COMT | Intergenic | Intergenic | ||||
|---|---|---|---|---|---|---|---|---|
| SNP | Rs165656 | Rs4633 | Rs2095019 | Rs4708592 | ||||
| Major allele (allele 1) | G | C | C | T | ||||
| Minor allele (allele 2) | C | T | A | C | ||||
| Association with disc degeneration previously reported in the literature | No | Yes 10;24 | No | No | ||||
| Raw P-value | 0.00113 | 0.001133 | 0.000833 | 0.001281 | ||||
| P-value (after multiple testing correction) |
0.043054 | 0.043054 | 0.031653 | 0.048662 | ||||
| Genotype Incidence (# (%)) | GG or GC | CC | CC or CT | TT | CC | CA or AA | TT | TC or CC |
| Grade I * | 1 (100%) | 0 (0%) | 1 (100%) | 0 (0%) | 0 (0%) | 1 (100%) | 0 (0%) | 1 (100%) |
| Grade II | 2 (33%) | 4 (67%) | 2 (33%) | 4 (67%) | 1 (17%) | 5 (83%) | 2 (33%) | 4 (67%) |
| Grade III | 9 (75%) | 3 (25%) | 9 (75%) | 3 (25%) | 4 (33%) | 8 (67%) | 7 (58%) | 5 (42%) |
| Grade IV | 13 (76%) | 4 (24%) | 13 (76%) | 4 (24%) | 13 (76%) | 4 (24%) | 16 (94%) | 1 (6%) |
| Grade V | 4 (100%) | 0 (0%) | 4 (100%) | 0 (0%) | 3 (75%) | 1 (25%) | 4 (100%) | 0 (0%) |
* Note the small sample size in the Grade I analysis (n=1) which was present here.