Table 5. Comparison of detected mutations between the pancreatic juice and resected tissue.
GNAS | KRAS | ||||||||
Case | Age | Sex | Diagnosis | IPMN-Type | Mutation | VF (%) | Mutation | VF (%) | |
1 | 73 | M | WT | G12R | 16.35 | ||||
WT | WT | ||||||||
2 | 62 | F | WT | G12V | 8.77 | ||||
PDAC without | WT | WT | |||||||
3 | 68 | M | IPMN | WT | G12D | 12.24 | |||
WT | WT | ||||||||
4 | 62 | M | WT | WT | |||||
WT | G12D | 23.03 | |||||||
5 | 82 | F | Branch | R201C | 5.47 | G12D | 6.45 | ||
R201C | 12.77 | WT | |||||||
6 | 73 | M | Branch | WT | G12V | 1.94 | |||
WT | G12V | 31.79 | |||||||
7 | 78 | F | Branch | WT | G12V | 6.46 | |||
WT | G12V | 12.79 | |||||||
8 | 72 | M | PDAC | Branch | R201H | 5.7 | G12D | 14.36 | |
concomitant | WT | WT | |||||||
9 | 63 | F | with IPMN | Branch | WT | G12D | 11.31 | ||
WT | WT | ||||||||
10 | 73 | M | Branch | WT | G12V | 25.44 | |||
WT | WT | ||||||||
11 | 80 | F | Branch | WT | G12D | 16.91 | |||
WT | WT | ||||||||
12 | 80 | M | Branch | R201H | 5.84 | WT | |||
WT | WT | ||||||||
13 | 72 | M | Main duct | R201C | 10.38 | G12V | 10.49 | ||
R201C | 27.82 | G12V | 21.62 | ||||||
14 | 69 | M | PDAC derived | Main duct | WT | WT | |||
from IPMN | R201C | 8.9 | G12V | 17.17 | |||||
15 | 37 | M | Branch | WT | WT | ||||
WT | WT | ||||||||
16 | 67 | M | Main duct | R201H | 10.53 | G12D | 16.2 | ||
R201H | 16.08 | G12D | 16.23 | ||||||
17 | 81 | M | Main duct | R201H | 46.62 | Q61H | 48.03 | ||
R201H | 14.39 | Q61H | 17.46 | ||||||
18 | 76 | M | Main duct | WT | G12D | 7.03 | |||
IPMN | WT | G12D | 17.28 | ||||||
19 | 78 | F | (Noninvasive) | Main duct | WT | G12V | 39.28 | ||
WT | G12V | 25.22 | |||||||
20 | 79 | F | Main duct | WT | Q61H | 10.54 | |||
WT | WT | ||||||||
21 | 62 | M | Branch | R201H | 39.39 | G12V | 38.31 | ||
R201H | 9.38 | G12D | 5.92 | ||||||
No. of detected mutations in tissue samples | 7 | 17 | |||||||
No. of pancreatic juice mutations identical to tissue samples | 5 | 7 | |||||||
Concordance rate of mutation | (%) | 71.4 | 41.2 |
Upper lines of each case indicate the results for tissue samples and lower lines indicate the results for pancreatic juice.
VF, Variant frequency; WT, wild type;
PDAC, pancreatic ductal adenocarcinoma; IPMN, intraductal papillary mucinous neoplasm.