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. Author manuscript; available in PMC: 2014 Jun 5.
Published in final edited form as: Bioorg Med Chem. 2006 Oct 20;15(2):915–930. doi: 10.1016/j.bmc.2006.10.036

Table 3.

In vivo (P. berghei) antimalarial activity of the 8-quinolinamine analogs 21–24

S. No. P. berghei (mg/kg/day×4, oral)
10 25 50 100
21 (2/6) Active (6/6) Curative (6/6) Curative (6/6) Curative
22 – (0/6) Inactive (6/6) Curative (6/6) Curative
23 – – (3/6) Active (6/6) Curative
24 (0/6) Inactive (6/6) Curative (6/6) Curative
Primaquine (PQ) – – – (0/6) Inactive

The term “curative” indicates complete elimination of malaria parasites from the body, and animals survive up to day D+60. The term “active” or “suppressive” indicates that all of the treated animals show negative parasitaemia up to D+7. However, by D+60, some mice die, and some survive with complete elimination of parasitaemia as indicated by numbers given in parentheses. The term “inactive” indicates that the treated animals show positive parasitaemia either on D+4 or D+7 and usually die by D+14.