Table 4.

In vitro antileishmenial (L. donovani) activity of the 8-quinolinamine analogs 21–33 and 51–63

	Leishmania donovani
S. No.	IC50 (μg/mL)	IC90 (μg/mL)
21	12	37
22	4.6	26
23	7.5	30
24	16	38
25	4	18
26	6.5	30
27	2.9	6.5
28	2.7	6.6
29	3	6.6
30	9.5	32
31	4.5	24
32	4	18
33	15	33
51	17	39
52	17	37
53	18	>40
54	19	>40
55	NA	NA
56	NA	NA
57	3.3	6.7
58	4.2	26
59	4.4	26
60	19	37
61	19	38
62	4.6	23
63	6	29
Primaquine (PQ)	19.9	NA

IC₅₀ and IC₉₀ are the sample conc that kill 50% and 90% cells compared to vehicle control

NA= no activity

Pentamidine. IC₅₀ = 1 μg/mL, IC₉₀ = 3.8 μg/mL

Amphotericin B. IC₅₀ = 0.19 μg/mL, IC₉₀ = 0.35 μg/mL