Table 4. Hazard ratio and adjusted hazard ratio for hospitalization due to cardiovascular events in patients aged more than 40 having their gout treated with allopurinol as compared those matched control receiving no allopurinol.

	Allopurinol cohort (%) (n = 2,483)	Non-allopurinol control (%) (n = 2,483)	HR (95% CI)	Adjusted HR (95% CI)
Cardiovascular Events	566 (22.80)	470 (18.93)	1.24*** (1.10–1.41)	1.25*** (1.10–1.41)
Coronary heart disease	158 (6.36)	111 (4.47)	1.44** (1.13–1.84)	1.41** (1.10–1.79)
Cerebrovascular disease (Stroke)	176 (7.09)	150 (6.04)	1.18 (0.95–1.47)	1.18 (0.95–1.47)
Hypertensive heart disease	538 (21.67)	419 (16.87)	1.34*** (1.18–1.52)	1.34*** (1.18–1.53)
Heart failure	141 (5.68)	92 (3.71)	1.55** (1.19–2.02)	1.52** (1.17–1.98)
Other	233 (9.38)	208 (8.38)	1.13 (0.94–1.36)	1.12 (0.93–1.35)

Adjustment was made for uremia, chronic kidney disease and gastric ulcer.

*P<0.05,

**<0.01,

***<0.001.

CI: confidence interval; HR: hazard ratio.