Table 5. Hazard ratio and adjusted hazard ratio for hospitalization due to cardiovascular events in patients or matched subjects aged more than 40 with gout and hyperuricemia receiving urate-lowering therapy, either allopurinol or uricosuric agent.

Urate-lowering therapy	Cardiovascular Events	Univariate Cox model		Adjusted Cox model
	N (%)	HR	95% CI	HR	95% CI
Allopurinol (n = 2483)	566 (22.80)	ref	ref	ref	ref
Uricosuric agents (n = 1713)	334 (13.45)	0.83**	0.72–0.95	0.83**	0.73–0.95

Adjustment was made for uremia, chronic kidney disease and gastric ulcer.

*P<0.05,

**<0.01,

***<0.001.

CI: confidence interval; HR: hazard ratio