Table 6. Univariate and multivariate hazard ratios (HR) for cardiovascular outcome in patient with gout receiving higher dosage of allopurinol as compared with low-dose allopurinol.

Allopurinol therapy	Cardiovascular events	Univariate		Multivariate
Daily dosage	Number (%)	HR	95% CI	HR	95% CI
<100 mg	85 (23.68)	Ref	-	Ref	-
100 mg	324 (25.67)	0.988	0.778–1.255	1.191	0.931–1.523
200 mg	92 (19.70)	0.731*	0.545–0.982	0.906	0.671–1.224
≥300 mg	65 (11.48)	0.669*	0.484–0.924	0.907	0.650–1.266

Multivariate HR was obtained after adjusting for chronic kidney disease, uremia, and gastric ulcer.

*P<0.05.

CI: confidence interval; HR: hazard ratio; Ref: reference.