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. 2014 May 16;7:301. doi: 10.1186/1756-0500-7-301

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Copyright © 2014 Garriga and Graña; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Hierarchical Cluster analysis of al treatments. (A) Genes with +/-1 log₂ ratios for treatments described in this study and [6] were clustered as described in the text and previous figures. Cell treatments are indicated on top. T indicates T98G cells, A indicates astrocytes, BJ indicates BJ-TERT fibroblasts. FVP treatments are indicated by F4, F8 or F24. Correlation distances are shown on the top of the arrays. A heat map legend is shown. (B) Schematic representation of the three strategies used to inhibit CDK9 activity, their mechanism, speed and potential off target effects.