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. 2014 Jun 4;9(6):e99089. doi: 10.1371/journal.pone.0099089

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© 2014 Liu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Confocal image of early-stage esophageal squamous carcinoma without the 4 features of the surface maturation score (SMS). B. Confocal image of low-grade neoplasia (LGN) without the 4 features of the SMS. C. Confocal image of reflux esophagitis, with the 2 SMS features existence and gradient but not polarity or compass effect, the red arrows show existence, and the green arrows show gradient.