Table 4.
Cost effectiveness (cost per life years saved) of vaccination strategies for moderate pandemics (R = 1.9 and CFR = 0.25%) and severe pandemics (R = 2.7 and CFR = 1.5%)
| |
Moderate pandemics (R = 1.9 and CFR = 0.25%) |
||
|---|---|---|---|
| Scenarios | SD and AV intervention |
Cost ($) per LYS |
|
| Pre-emptive vaccination | Reactive vaccination | ||
|
Scenario 1: no pandemic occurs |
none |
- |
- |
| |
Pre-emptive + Reactive vaccination |
Reactive vaccination |
|
|
Scenario 2: pandemic with virus which does not match pre-emptive vaccine i.e. vaccine efficacy of 0% |
none |
$1,627,500 |
$1,020,000 |
| 8 weeks SD + AV |
$29,684 |
$20,079 |
|
| Sustained SD + AV |
$24,846 |
$19,074 |
|
| |
Pre-emptive vaccination |
Reactive vaccination |
|
|
Scenario 3: pandemic with virus which matches pre-emptive vaccine with efficacy of 30% |
none |
$13,622 |
$1,020,000 |
| 8 weeks SD + AV |
$12,096 |
$20,079 |
|
| Sustained SD + AV |
$15,897 |
$19,074 |
|
| |
Pre-emptive vaccination |
Reactive vaccination |
|
|
Scenario 4: pandemic with virus which matches pre-emptive vaccine with efficacy of 75% |
none |
$8,013 |
$1,020,000 |
| 8 weeks SD + AV |
$10,435 |
$20,079 |
|
| Sustained SD + AV |
$13,658 |
$19,074 |
|
| |
Extreme pandemics (R = 2.7 and CFR = 1.5%) |
||
|
Scenarios |
SD and AV intervention |
Cost ($) per LYS |
|
|
Pre-emptive vaccination |
Reactive vaccination |
||
|
Scenario 1: no pandemic occurs |
none |
- |
- |
| |
Pre-emptive + Reactive vaccination |
Reactive vaccination |
|
|
Scenario 2: pandemic with virus which does not match pre-emptive vaccine i.e. vaccine efficacy of 0% |
none |
$1,942,222 |
$1,672,222 |
| 8 weeks SD + AV |
$12,305 |
$10,312 |
|
| Sustained SD + AV |
$4,938 |
$4,044 |
|
| |
Pre-emptive vaccination |
Reactive vaccination |
|
|
Scenario 3: pandemic with virus which matches pre-emptive vaccine with efficacy of 30% |
none |
$6,066 |
$1,672,222 |
| 8 weeks SD + AV |
$3,097 |
$10,312 |
|
| Sustained SD + AV |
$2,811 |
$4,044 |
|
| |
Pre-emptive vaccination |
Reactive vaccination |
|
| Scenario 4: pandemic with virus which matches pre-emptive vaccine with efficacy of 75% | one |
$1,075 |
$1,672,222 |
| 8 weeks SD + AV |
$1,454 |
$10,312 |
|
| Sustained SD + AV | $1,986 | $4,044 | |