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. 2014 May 19;12:36. doi: 10.1186/1741-7007-12-36

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Copyright © 2014 Krupovic et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Proposed mechanisms of casposon replication and integration. (a) Mechanism of casposon DNA excision and replication. (b) Mechanism of spacer acquisition by CRISPR-Cas system. Adapted from [34]. (c) Proposed mechanism of Cas1-mediated casposon integration. See text for details. Subterminal regions within TIRs outlined with the broken line indicate that processing occurs only in a fraction of casposons. See text for details. Abbreviations: TIR, terminal inverted repeats; TSD, target site duplication.

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