Table 5. Sensitivity analysis – adjustment for BMI, diabetes and smoking hazard ratios for one log₂ (i.e. doubling) increment in biomarkers ESPRIT, SMART and SILCAAT.

	CRP		D-dimer		IL-6
	HRb	P	HRb	P	HRb	P
Any cancer
Full adjustmenta	1.16	0.001	1.17	0.03	1.38	<0.001
No. of patients (events)	5022 (172)		5006 (171)		4994 (171)
Full adjustment + BMI	1.16	<0.001	1.16	0.04	1.37	<0.001
No. of patients (events)	4948 (170)		4932 (169)		4920 (169)
Full adjustment + smoking (SMART)	1.10	0.20	1.12	0.28	1.37	0.006
No. of patients (events)	2541 (58)		2526 (57)		2514 (57)
Full adjustment + diabetes (SMART and ESPRIT)	1.15	0.008	1.14	0.10	1.42	<0.001
No. of patients (events)	4307 (128)		4291 (127)		4279 (127)
Infection-related cancer
Full adjustmenta	1.18	0.02	1.19	0.13	1.42	0.002
No. of patients (events)	5022 (70)		5006 (70)		4994 (70)
Full adjustment + BMI	1.18	0.02	1.19	0.15	1.40	0.004
No. of patients (events)	4948 (69)		4932 (69)		4920 (69)
Full adjustment + smoking (SMART)	1.15	0.30	1.25	0.22	1.45	0.07
No. of patients (events)	2541 (18)		2526 (18)		2514 (18)
Full adjustment + diabetes (SMART & ESPRIT)	1.20	0.03	1.25	0.08	1.56	<0.001
No. of patients (events)	4307 (51)		4291 (51)		4279 (51)
Infection-unrelated cancer
Full adjustmenta	1.15	0.02	1.15	0.12	1.35	0.002
No. of patients (events)	5022 (102)		5006 (101)		4994 (101)
Full adjustment + BMI	1.15	0.02	1.15	0.13	1.35	0.002
No. of patients (events)	4948 (101)		4932 (100)		4920 (100)
Full adjustment + smoking (SMART)	10.08	0.39	1.06	0.65	1.35	0.04
No. of patients (events)	2541 (40)		2526 (39)		2514 (39)
Full adjustment + diabetes (SMART & ESPRIT)	1.12	0.10	1.08	0.45	1.32	0.02
No. of patients (events)	4307 (77)		4291 (76)		4279 (76)

CRP, C-reactive protein.

^aStratified by study and adjusted for demographics (age, race, sex, continent), and study entry and time-updated CD4⁺ cell counts.

^bHR, hazard ratio for one log₂ increase in indicated biomarker.