Table 2.

Associations between CypA levels and Asthma Parameters
	n=137		Cluster 1 (n=55)		Cluster 2 (n=31)		Cluster 3 (n=51)
Continuous Variables	(95% CI)	p value	(95% CI)	p value	(95% CI)	p value	(95% CI)	p value
Log ECP	0.204 (0.089, 0.319)	0.001	0.123 (−0.027, 0.277)	0.106	0.333 (−0.075, 0.741)	0.101	0.274 (0.07, 0.478)	0.01
P-selectin	0.418 (0.153, 0.683)	0.002	0.553 (0.142, 0.965)	0.01	0.346 (−0.363, 1.054)	0.298	0.224 (−0.140, 0.588)	0.214
Log FEV1 ,prebronchodilator	2.157 (−0.212, 4.526)	0.074	3.749 (0.218, 7.28)	0.038	1.882 (−4.432, 8.196)	0.544	0.13 (−3.631, 3.892)	0.945
Log FEV1 change with bronchodilator	−2.973 (−4.887, −1.059)	0.003	−4.009 (−7.007, −1.012)	0.01	−1.937 (−5.410, 1.535)	0.261	−1.823 (−5.336, 1.69)	0.31
NAEPP Severity Classification	0.148 (−0.093, 0.389)	0.229	0.270 (−0.079, 0.619)	0.129	−0.72 (−0.812, 0.668)	0.849	0.018 (−0.410, 0.446)	0.935

Associations between CypB levels and Asthma Parameters
	n=137		Cluster 1 (n=55)		Cluster 2 (n=31)		Cluster 3 (n=51)
Continuous Variables	(95% CI)	p value	(95% CI)	p value	(95% CI)	p value	(95% CI)	p value
Log ECP	0.31 (−0.152, 0.772)	0.186	−0.21 (−0.833, 0.791)	0.958	0.638 (−0.709, 1.984)	0.325	0.562 (−0.107, 1.232)	0.096
P-selectin	0.842 (0.018, 1.665)	0.045	2.685 (0.497, 4.874)	0.018	−0.239 (−2.558, 2.081)	0.821	0.590 (−0.527, 1.707)	0.284
Log FEV1, prebronchodilator	3.668 (−5.45, 12.786)	0.428	−0.689 (−19.982, 18.604)	0.943	12.889 (−5.959, 31.736)	0.171	0.576 (−10.856, 12.008)	0.92
Log FEV1 change with bronchodilator	−0.268 (−0.7828, 0.7292)	0.944	2.124 (−14.672, 18.919)	0.8	−0.364 (−11.356, 10.628)	0.946	0.02 (−10.792, 10.831)	0.997
NAEPP Severity Classification	0.462 (−1.367, 0.444)	0.318	0.370 (−1.321, 2.061)	0.668	−1.548 (−3.973, 8.77)	0.211	−0.279 (−1.562, 1.003)	0.669

Associations between MCP-1 levels and Asthma Parameters
	n=137		Cluster 1 (n=55)		Cluster 2 (n=31)		Cluster 3 (n=51)
Continuous Variables	(95% CI)	p value	(95% CI)	p value	(95% CI)	p value	(95% CI)	p value
Log ECP	0.209 (0.10, 0.318)	<0.001	0.215 (0.051, 0.380)	0.011	0.322 (0.033, 0.612)	0.032	0.066 (−0.169, 0.302	0.566
P-selectin	0.349 (0.113, 0.585)	0.004	0.463 (−0.034, 0.961)	0.067	0.340 (−0.178, 0.858)	0.172	0.170 (−0.208, 0.547)	0.36
Log FEV1, prebronchodilator	−0.1906 (−4.171, 0.360)	0.098	−2.404 (−6.566, 1.757)	0.251	−0.484 (−5.356, 4.387)	0.839	−2.458 (−6.215, 1.299)	0.194
Log FEV1 change with bronchodilator	0.54 (−1.352, 2.431)	0.573	0.672 (−2.997, 4.342)	0.714	−0.335 (−3.064, 2.394)	0.802	0.188 (−3.434, 3.810)	0.917
NAEPP Severity Classification	0.232 (0, 0.464)	0.05	−0.042 (−0.409, 0.325)	0.823	0.239 (−0.442, 0.919)	0.492	0.498 (0.045, 0.095)	0.031

Notes: ECP = Eosinophil Cationic Protein;

FEV₁ = Forced expiratory volume in 1 second; NAEPP = National Asthma Education and Prevention program, 2007 Criteria.