Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model for MUC16-induced NK cell inhibition. MUC16 released from tumors binds to naïve NK cells (shown in red) and along with other tumor derived factors induces a phenotypic and functional change. The altered NK cells (shown in blue) secrete cytokines that promote angiogenesis. The cell surface bound MUC16, on the other hand, acts as an anti-adhesive mucin and blocks the interaction between the NK cells and ovarian tumor cells thereby preventing cancer cell cytolysis.
