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Effect of diet and CYP27A1 genotype on CYP7A1 and HMGR activities in the liver. Conversion of cholesterol to 7α-cholesterol (A) and HMGCo-A to mevalonic acid (B) was measured in liver microsomes of ApoE-KO, het, and DKO mice fed for 3 mo with CD or WD as described in Materials and Methods. Results are presented as means ± sd of triplicate determinations (n=3 animals/condition). *P < 0.05, **P < 0.01, ***P < 0.001.
