Table 2.
The Effect of ALB Variants with Increased Affinities for Iodothyronines on Iodothyronine Concentrations in Serum
| TT4 (μg/dL) | TT3 (ng/dL) | TrT3 (ng/dL) | n | |
|---|---|---|---|---|
| WT | 8.0±0.2 | 125±4 | 22.5±0.9 | 83 |
| R218H | 16.0±0.5 | 154±3 | 33.1±1.1 | 84 |
| (2.0) | (1.2) | (1.5) | ||
| R218S | 70 | 159 | 55.7 | 1 |
| (This report) | (8.8) | (1.3) | (2.6) | |
| R218P | 135±17 | 241±25 | 136±13 | 8 |
| (16.8) | (1.9) | (6.1) | ||
| L66P | 8.1±0.6 | 326±21 | 22.3±0.9 | 6 |
| (1.0) | (2.6) | (1.0) |
Values reported are means±standard error, and the number of subjects per genotype are under “n.” Note that for ALB R218S, only one subject is listed, as the second subject with the same defect also had elevated TBG due to estrogen-containing contraception. Numbers in parentheses indicate the fold above the mean normal value for the WT ALB R218. All data were generated in the Chicago laboratory except for four of the eight individuals with ALB R218P.