Table 2.

Comparison of Clinical and Pathological Characteristics Between Hobnail PTC Cases of Published Case Series and the Cases in the Present Study

Study (# cases)	F:M	Age (years)*	Inclusion criteria	Tumor size (cm)*	% pTNM Stage III/IV	LVI (%)	Lymph node metastasis (%)	Distant metastasis (%)	Follow-up (mo)#	Disease-specific survival (%)
Asioli et al. 2012 (29) (n=24)	18:6	57.3±12.0	Nonsolid type PTC; ≤10% tall/columnar or diffuse sclerosing features; loss of polarity/cohesiveness with hobnail/micropapillary features in ≥10% of tumor cells; available clinical and follow-up data and pathologic material	3.0±1.7	58.3	70.8	60.9	43.5	95 (21–165)	66.6
Lino-Silva et al. 2012 (14) (n=7)	3:4	45.9±13.4	Neoplastic cells with papillary morphology, abundant, clear or oncocytic cytoplasm, without true fibrovascular cores, surrounded by a clear halo of fibers surrounded by fibrous stroma; pleomorphic and hyperchromatic nuclei; nuclear grooves; reverse polarity	4.4±0.3	71.4	71.4	57.1	42.9	69 (64–74)	42.9
Present study (n=12)	9:3	54.1±18.8	Hobnail features in >30% of the tumor; TCF in <30% of the tumors	3.7±2.0	58.3	41.7	75.0	25.0	26 (14–35.5)	90.9

^*Mean age±standard deviation; ^#median (interquartile range).