FIG. 4.
Negative correlation between the frequency of HIV-specific LAG-3+CD8+ T cells and HIV plasma RNA. The percentage of Gag-specific LAG-3 is plotted against the HIV plasma RNA. A significant negative correlation between HIV plasma RNA and Gag-specific LAG-3+CD8+ T cells in (A) was observed (rs=−0.51, p=0.0008). (B) Increased LAG-3 expression is also observed in antiretroviral treatment (ART)-mediated viral suppression compared to samples from individuals with CD4 <200 plasma viral load (pVL) >100 and CD4 >200 pVL >100 (p=0.02 and p=0.008, respectively); CD4 >200 (n=19), CD4 <200 (n=9), ART (n=5). Spearman rank correlations with p values<0.05 were considered significant.