Table 2.
Effect of Zataria multiflora on body weight, water and food intake and other insulin resistance related parameters
| Parameter | Groups | P-value¥ | |||
|---|---|---|---|---|---|
| HCG | Con | Pio | ZME | ||
| initial weight (g) | 275±8 | 272±9 | 272±12 | 281±12 | 0.586 |
| weight after 8 week (g) | 285±9 | 307±8 | 294±16 | 282±15 | 0.832 |
| Weight gain (g) | 10±2* | 35±2# | 22±5# | 11±6* | <0.0001 |
| Water intake (ml) | 35±0.8* | 47±2# | 60±2#* | 54±3# | 0.221 |
| Food intake (g) | 21.6±0.7* | 13.4±0.4# | 13.5±0.3# | 13±0.2# | 0.779 |
| Insulin (pmol/L) | 50±4.8* | 137±34# | 40±2.7* | 43±11* | 0.007 |
| Adiponectin (μg/ml) | 2.9±0.16 | 3.9±0.15 | 5.6±0.4# * | 5.3±0.5# * | 0.029 |
| Glucose (mg/dl) | 132±4* | 187±15# | 129±5.8* | 144±9.8* | 0.029 |
| HOMA.IR | 2.7±0.37* | 9.7±2.1# | 2.1±0.12* | 2.6±0.74* | 0.001 |
| Cholesterol (mg/dl) | 71±12.1 | 59±3.2 | 63±4.2 | 54±2.9 | 0.955 |
| Triglyceride (mg/dl) | 85±13* | 217±18# | 200±51# | 120±10#* | 0.011 |
| HDL-c (mg/dl) | 24.86±1.4 | 29.25±1.8 | 29.38±2.3 | 26.35±1.2 | 0.668 |
HCG was fed standard chow and three other groups were fed 60% fructose diet for 8 weeks. In Pio and Z. multiflora groups after primary 6 weeks, animals were treated by pioglitazone (10 mg/kg/day) or Z. multiflora extract (1000 mg/kg/day) for 2 week. Biochemical parameters were assayed by auto analyzer and hormones by ELISA kits. HOMA-IR was calculated by the formula. All data are Mean± SEM. (n=8)
HCG: healthy control group, Con: control, Pio: pioglitazone, ZME: Zataria multiflora extract
¥ P-value demonstrates the difference significance between Zataria multiflora and control group.
* Significant difference with control group P<0.05)
# Significant difference with HCG group (P<0.05)