Table 2.

Effect of oxygen therapy on serum malondialdehyde and renal function markers in gentamicin induced nephrotoxicity

Experimental groups	Serum MDA (nmol/ml)	Serum creatinine (mg/dl)	Serum urea (mg/dl)	Urine creatinine (mg/dl)	Urine urea (mg/dl)
1	0.23 ± 0.027	0.69± 0.04	56.8 ±5.14	2.04 ± 0.07	168.6 ± 13.04
2	0.701 ± 0.056 *	2.98± 0.25 *	198.42 ±16.58 *	0.78 ± 0.07 *	40 ± 6.56 *
3	0.543 ± 0.045 *	2.7± 0.40 *	160.14± 13.21 *	0.67 ± 0.16*	44.7 ± 7.19 *
4	0.504 ± 0.705 *	1.60± 0.06 * #	120.5 ± 5.25 * #	1.301 ± 0.10 * #	80.07 ± 5.43 * #
5	0.505 ± 0.051 *	2.77 ± 0.45 *	192.3 ± 17.63 *	0.55 ± 0.13 *	30.66 ± 6.67 *
6	0.414 ± 0.026 * #	1.77 ± 0.17 * #	117.66 ± 5.38 * #	1.26 ± 0.05 * #	74.25 ± 5.6 * #

Values represented as mean ±SEM. * Significant change in comparison with control At P < 0.05. # Significant change in comparison with gentamicin only treated at P < 0.05. group 1 as control; group 2 received daily GS (100 mg/kg Ip); group 3 received oxygen 2 hr daily for 2 days and then received daily GS; group 4 received oxygen 4 hr daily for 2 days and then received daily GS; group 5 received oxygen 4 hr daily for 4 days and then received daily GS and group 6 received oxygen 2 hr daily for 2 days and then during daily injection GS received 2 hr oxygen before injection