Fig. 1.

Representative pacemaker current recordings of human atrial myocytes.

Pacemaker currents (pA) were recorded by hyperpolarizing voltage steps ranging from − 40 to − 130 mV (10 mV increment, holding potential − 40 mV, 3 s duration) and normalized to cell capacitance (pF) for a control cell (A) and for cells treated with indicated concentrations of ivabradine (7 min) (B), S-LPS (6 h) (C) or R595 (6 h) (D). Arrows indicate current at − 70 mV.