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. Author manuscript; available in PMC: 2015 May 7.
Published in final edited form as: Neuron. 2014 May 7;82(3):587–602. doi: 10.1016/j.neuron.2014.04.009

Figure 6. Tnfr1−/− and Tnf −/− mice are hypersensitive to thermal and mechanical stimuli.

Figure 6

(A–E) Behavioral sensitivity of WT, Tnfr1−/−, and Tnf −/− mice in response to the tail flick (A), Hargreaves radiant heat (B), acetone drop (C), hot plate (D), and von Frey (E) tests measuring reflexive (A–B) or centrally-mediated (C–D) thermal pain thresholds or mechanical acuity (E).

n=6 mice per data point (aged P26-P56), if n>6 mice, it is indicated. 2-way (A,D,E) or 1-way (B,C) ANOVA, Bonferroni post-test. All mice shown are on a B6;129s mixed background. WT mice are background matched, non-littermate controls for Tnfr1−/− and Tnf −/− mice.

See also Figure S5.

Data represent mean±SEM, ns: not significant, *p<0.05, **p<0.01, ***p<0.001.