Table 1.
Tim-3 expression (%) and (MFI) according to demographic and clinical parameters with well-known prognostic value
| Demographic and clinical parameters | Number of patients (N=83(%)) | Tim-3+ cells (%) Mean(SD) | P value | Tim-3+ cells (MFI) Mean(SD) | P value | |
|---|---|---|---|---|---|---|
| Age Groupsa | <= 45y | 22 (27) | 71.77(10.78) | 0.4122 | 31.30(5.953) | 0.9363 |
| 46-70y | 30 (36) | 69.51(13.52) | 30.94(6.650) | |||
| >=71y | 31 (37) | 66.34(18.15) | 30.62(7.319) | |||
| Genderb | Female | 27 (33) | 69.19(12.67) | 0.7544 | 30.09(6.630) | 0.4382 |
| Male | 56 (67) | 69.28(15.85) | 31.31(6.701) | |||
| Stagea | I | 47 (56) | 66.01(15.78) | 0.2116 | 29.07(5.303) | 0.0114 |
| II | 18 (22) | 69.93(17.45) | 32.39(7.895) | |||
| III/IV | 18 (22) | 73.28(9.973) | 34.30(8.479) | |||
| Thicknessb | <=1mm | 47 (57) | 66.03(15.47) | 0.041 | 29.18(5.642) | 0.0059 |
| >1mm | 36 (43) | 72.70(13.20) | 33.18(7.166) | |||
| Mitotic Indexb | <1/mm2 | 35 (42) | 65.01(15.83) | 0.0056 | 29.28(5.771) | 0.0278 |
| >=1/mm2 | 42 (51) | 73.54(10.21) | 32.46(6.540) | |||
| Unclassified | 6 (7) | |||||
| Ulcerationb | Absent | 58 (70) | 67.51(15.34) | 0.0351 | 30.19(6.263) | 0.0466 |
| Present | 19 (23) | 75.58(9.979) | 33.61(6.811) | |||
| Unclassified | 6 (7) | |||||
| LN statusb | Negative | 70 (84) | 68.24(15.58) | 0.3280 | 30.85(6.875) | 0.8242 |
| Positive | 13 (16) | 72.64(9.389) | 31.30(5.647) | |||
| Metastasisb | Absent | 74 (89) | 68.10(15.22) | 0.1476 | 30.26(6.105) | 0.0092 |
| Present | 9 (11) | 75.70(8.996) | 36.31(8.840) | |||
a
One-way analysis of variance (ANOVA);
b
Unpaired T test