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Prior stress increases implant frequency and severity. None of the sham-stress animals developed vesicles. The endo-no stress group developed a vesicle in 50% of their sutures (grades 2, 3, or 4). Prior exposure to stress increased both, (A) the number of vehicles developed and (B) the average vesicle grade (9-10 animals/group; *P < .05 vs endo-no stress).
