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. 2014 May 30;14:387. doi: 10.1186/1471-2407-14-387

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Copyright © 2014 Banyard et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Development of a model of metastatic prostate cancer through repeated selection of spontaneous lymph node metastases from orthotopic DU145 human prostate tumors. Schematic (left panels) of the experimental approach shows orthotopic prostate inoculation of DU145 cells. Lymph nodes were removed and cultured, and selected tumor cells subject to repeated rounds of orthotopic injection. Right panels show gross anatomy of tumors and lymph nodes 5 weeks after all DU145 sublines were reinjected (this figure is modified with permission from [21]). Scale bar = 1 cm.