Table 1.
Recommended Antiemetic Regimens for CINV Prophylaxis
| Emetic risk | Treatment for acute phasea | Treatment for delayed phase |
|---|---|---|
| High | 3-drug combination treatment with an NK1 receptor antagonist, a 5-HT3 receptor antagonist, and dexamethasone | NK1 receptor antagonist if oral route was used; dexamethasone |
| Moderate | 2-drug combination treatment with a 5-HT3 receptor antagonist and dexamethasone | Dexamethasone |
| Low | Dexamethasone | |
| Minimal | No routine prophylaxis recommended |
a
All patients should have “as-needed” rescue medication available, which can include prochlorperazine, promethazine, or lorazepam, regardless of emetic risk level.
5-HT indicates serotonin; CINV, chemotherapy-induced nausea and vomiting; NK, neurokinin.