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Pharmacokinetic Properties of 5-HT3 Receptor Antagonists
| Agent | Ondansetron | Granisetron | Dolasetron | Palonosetron |
|---|---|---|---|---|
| Half-life (hrs) | 3–4 | 7–9 | 7–8 | 40 |
| Oral bioavailability, % | 56 | 60 | 75 | N/A |
| Renal elimination, % | 5 | 12 | 67 | 42 |
| Hepatic metabolism | CYP-3A, CYP-1A, CYP-2D6, CYP-2E1 | CYP-3A | CYP-3A, CYP-2D6 | CYP-3A4, CYP-2D6, CYP-1A2 |
5-HT indicates serotonin; CYP, cytochrome P; N/A, not applicable.
