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. 2014 Apr;60(4):345-350.

Table 2.

Medication care plan

DRUG-RELATED PROBLEM ACTION PLAN MONITORING
Medications that might contribute to cognitive decline symptoms and fall risk:
  • Chlordiazepoxide

  • Clidinium

  • Amitriptyline (also contributing to QT prolongation with erythromycin and domperidone)

  • Stop chlordiazepoxide and clidinium (tapering not required owing to long benzodiazepine half-life

  • Taper amitriptyline to 150 mg at bedtime and consult with geriatric psychiatrist regarding further tapering

Benzodiazepine withdrawal starting at 7–10 days, then for 6 weeks after stopping: insomnia, anxiety, etc Improvement in cognitive symptoms Improvement in anticholinergic symptoms (eg, dry mouth, constipation, dizziness)
Constipation-diarrhea cycle might be contributed to by periodic overuse of psyllium laxative and lactulose, followed by loperamide
  • Change to routine psyllium laxative 1 tbsp daily (each morning with water) and lactulose 1–2 tbsp every 2–3 days if no bowel movement

  • Will provide IBS symptom diary

Bowel movements (IBS diary); need for loperamide
Might not require all 3 of erythromycin, domperidone, and pinaverium; risk of additive side effects (eg, diarrhea, nausea, vomiting, QT prolongation)
  • Once psyllium laxative and lactulose use is stable, consider tapering erythromycin

  • Taper domperidone when effect of erythromycin is known

  • Taper pinaverium once effect of above is known

Bowel movements (IBS diary)
With domperidone tapering, monitor for worsening symptoms of esophageal spasms or reflux
Ongoing heartburn (with esophageal strictures); might need lansoprazole increase
  • Increase lansoprazole to 30 mg twice daily

Heartburn; use of calcium carbonate antacids
Half-capsule of acetylsalicylic acid, butalbital, codeine, and caffeine, and acetaminophen with codeine might be contributing to heartburn, constipation, dizziness, and confusion; limited effectiveness of each
  • Will discuss limiting acetylsalicylic acid, butalbital, codeine, and caffeine dosing with patient

  • Reduce acetaminophen with codeine to 1 only for “tight band” headache

Esophageal spasms
Headache
BP higher than target; might benefit from ramipril increase
  • Increase ramipril to 5 mg

Cough; serum creatinine and electrolyte levels in 1–2 weeks
BP target < 140/90 mm Hg
At risk of additive side effects owing to overuse of 2 short-acting β2-agonists
  • Stop regular terbutaline inhaler and use only salbutamol inhaler as needed, with hand-grip attachment and antistatic valved holding chamber if necessary

Ability to use salbutamol inhaler

BP—blood pressure, IBS—irritable bowel syndrome.