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. 2014 Jun 5;8:204. doi: 10.3389/fnbeh.2014.00204

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Copyright © 2014 Dinces, Romeo, McEwen and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental methods. (A) Timeline. PND: postnatal day. (B) Sequential steps in the neonatal novelty exposure procedure (split-litter design, PND 1–21): after the assignment of pups to neonatal novelty exposure conditions (NeoN, NeoH), the following is performed daily. (1) Dam is removed from the home cage; (2) Novel and Home pups (NeoN, NeoH) are sorted into the two small compartments, Novel pups are transferred to individual non-home cages and Home pups are transferred to individual compartment in home cage, both receiving the same amount of experimenter touch; (3) After 3 min, Novel and Home pups were both returned to the home cage; and (4) After all dividers are removed, dam is returned to the home cage. (C) Early Adulthood novelty exposure (PND 54–63): the following is performed daily. Right: the Adult_N rats (Neo_H-Adult_N = HN; Neo_N-Adult_N = NN) were transported to the exposure room and placed in the open field for 3 min; Left: Adult_H rats (Neo_H-Adult_H = HH; Neo_N-Adult_H= NH) were picked up twice and replaced back into their home cage in the housing room.