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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: J Cardiovasc Pharmacol. 2014 Apr;63(4):369–374. doi: 10.1097/FJC.0000000000000057

Table 2. Comparison of oxidative stress markers, inflammatory markers, vascular function measures, and endothelial progenitor cells after the clopidogrel and placebo treatment periods (n=41).

Characteristics Clopidogrel (Mean ± SE) Placebo (Mean ± SE) p-value
Oxidative Stress Markers (Mean ± SE)
Cystine (μM) 105.25 ± 7.36 102.39 ± 7.29 0.71
Cysteine (μM) 13.71 ± 0.90 14.75 ± 0.89 0.39
Eh Cysteine/Cystine Ratio -77.06 ± 1.76 -78.72 ± 1.74 0.73
Glutathione (μM) 1.52 ± 0.17 1.71 ± 0.17 0.28
Oxidized Glutathione (μM) 0.08 ± 0.06 0.19 ± 0.06 0.19
Eh Glutathione/Oxidized Glutathione Ratio -130.62 ± 2.30 -128.47 ± 2.27 0.47
Inflammatory Markers (Mean ± SE)
Hs-CRP (mg/l) 5.98 ± 1.95 4.31 ± 1.95 0.55
CD40 Ligand (pg/ml) 1202.21 ± 318.35 2169.32 ± 318.35 0.03*
Vascular Function (Mean ± SE)
Flow-mediated vasodilation (%) 4.89 ± 0.59 4.81 ± 0.59 0.89
Nitroglycerin-mediated vasodilation (%) 19.31 ± 1.49 17.10 ± 1.51 0.17
Reactive Hyperemia Index 2.50 ± 0.80 2.20 ± 0.70 0.29
Augmentation Index at 75 beats per minute 25.04 ± 1.63 23.64 ± 1.62 0.26
Pulse Wave Velocity (m/s) 8.77 ± 0.45 9.044 ± 0.45 0.46
Endothelial Progenitor Cells (Mean ± SE)
CD34+ (cells/μl) 1.46 ± 0.16 1.54 ± 0.21 0.77
CD34+/CD133+ (cells/μl) 0.68 ± 0.07 0.75 ± 0.16 0.71
CD34+/VEGF2R+ (cells/μl) 0.08 ± 0.03 0.09 ± 0.02 0.70
CD34+/CD133+/VEGF2R+ (cells/μl) 0.03 ± 0.009 0.03± 0.008 0.96