TABLE 3.

LightCycler quantification of C. albicans ERG11, CDR1, CDR2, and MDR1 mRNA

Isolate no.	Susceptibility interpretationb	Mean expression units ± SDa
		ERG11c	CDR1d	CDR2d	MDR1
1	R	3.98 ± 0.64	4.89 ± 0.86	1.21 ± 0.16	0
2	R	5.39 ± 0.56	4.33 ± 0.76	1.71 ± 0.29	0.20 ± 0.03
3	R	4.78 ± 0.63	8.35 ± 0.16	0.85 ± 0.09	0.63 ± 0.16
4	SDD	3.90 ± 0.45	5.16 ± 0.44	2.01 ± 0.28	0
5	SDD	2.35 ± 0.46	13.14 ± 1.43	1.01 ± 0.15	0.61 ± 0.14
6	SDD	3.97 ± 0.50	5.04 ± 0.60	2.82 ± 0.45	0
7	SDD	2.52 ± 0.40	2.42 ± 0.49	0.62 ± 0.04	156.50 ± 11.63
8	S	2.08 ± 0.32	2.43 ± 0.83	0.26 ± 0.05	0
9	S	1.87 ± 0.08	1.43 ± 0.22	0.30 ± 0.02	0
10	S	1.56 ± 0.27	2.06 ± 0.22	0.24 ± 0.05	0

^aGene expression normalized to ACT1 expression for each isolate.

^bFluconazole susceptibility category (R, resistant; SDD, susceptible dose dependent; S, susceptible).

^cOverexpression in R compared to S and SDD isolates and in SDD compared to S isolates (P ≤ 0.05).

^dOverexpression in R compared to S isolates (P ≤ 0.08).