Table I.
New genetic factors associated with SLE.
Gene | Pathway | Reference |
---|---|---|
ITGAM/CD11b | Macrophage activation | [5] |
IRAK1 | NF-kappaB activation | [26] |
TREX1 | IFN-α production | [27,28] |
STAT4 | Cytokine signaling | [23] |
IRF-5 | Cytokine signaling | [24] |
PTPN22 | Sustained TCR/BCR signaling | [29,30] |
BANK1 | Sustained BCR signaling | [68] |
B-lymphocyte kinase | B cell activation | [69] |
HRES-1/Rab4 | Receptor recycling | [13,15] |
Coronin-1A | Actin depolymerization | [62] |
MtDNA | Electron transport | [32] |