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. Author manuscript; available in PMC: 2015 May 2.
Published in final edited form as: Brain Res. 2014 Mar 15;1561:11–22. doi: 10.1016/j.brainres.2014.03.002

Fig. 2.

Fig. 2

Estradiol and Tamoxifen treatment promotes white matter sparring during SCI. A: The extent of the lesion cavity in treated and non-treated rats was performed by tissue staining with Luxol (SE-Silastic Empty; E2- Estradiol; MPP- MPP dihydrochloride [estrogen receptor alpha antagonist]; TAM- Tamoxifen). B: Densitometry analysis to determine the lesioned area was performed at 28 DPI using MCID, Imaging Research, Inc. Estradiol (E2) treated rats show a significant increase in white matter tissue at 28 DPI and the effect is mediated through the estrogen receptor alpha because the effect was blocked with MPP dihydrochloride. Rats treated with TAM show a significant white matter sparring at 28 DPI when compared to control, according to One-way ANOVA and Dunnet’s Multiple Comparison post-hoc (n=at least 3, *p<0.05; **p<0.01).