Table 2.
Summary of the chromosomal regions associated with blood lipids at the genome-wide significance level
| Trait | population | Top SNPs | Num. of SNPa | Position (bp)b | Phenotypic variance (%)c | P-value | candidate gened |
|---|---|---|---|---|---|---|---|
| TC | F2 | ASGA0016328 | 2 | SSC3: 124,769,847 | 7.60 | 2.03 × 10-7 | APOB |
| Sutai | MARC0101455 | 3 | SSC2: 56,469,735 | 9.75 | 4.40 × 10-8 | CRTC1, CERS1 | |
| Sutai | DIAS0002715 | 4 | SSC2: 70,246,409 | 8.83 | 5.76 × 10-8 | SMARCA4, LDLR | |
| Sutai | ALGA0109254 | 1 | SSC5: 3,550,340 | 13.34 | 2.05 × 10-7 | Undetected | |
| LDL-C | F2 | ASGA0090960 | 1 | SSC1: 63,541,683 | 11.66 | 2.69 × 10-8 | Undetected |
| F2 | ASGA0016328 | 3 | SSC3: 124,769,847 | 9.80 | 1.90 × 10-10 | APOB | |
| Sutai | M1GA0002939 | 15 | SSC2: 60,318,677 | 16.27 | 8.27 × 10-11 | CRTC1, SLC27A1, CERS1 | |
| Sutai | DIAS0002715 | 25 | SSC2: 70,246,409 | 14.26 | 1.17 × 10-12 | SMARCA4, LDLR, | |
| HDL-C/LDL-C | Sutai | MARC0002082 | 1 | SSC2: 76265092 | 7.34 | 4.43 × 10-7 | GNA11, ABCA7 |
a.The number of genome-wide significant SNPs within the QTL regions.
b.Positions of the top SNPs on the Sus Scrofa Build 10.2 assembly.
c.Phenotypic variance explained by the top SNPs.
d.The candidate genes were searched from annotated genes with functional relevance to serum lipids in an interval of 5.0 Mb centered at the top SNP at each significant locus. Undetected, no apparent candidate gene was detected in the corresponding genomic locus.