Table 5.
Chromosomal Regions with Trait Associated SNPs (TAS) affecting IMF fatty acid (FDR = 0.05)
| SSC | Trait | Chromosomal region (Mb) | N° of TAS | P-value | a (SE) | Ref§ |
|---|---|---|---|---|---|---|
| 1 | C16:0IMF | 52.52-84.70 | 106 | 8.5 × 10-6 | −0.57 (0.12) | [11] |
| 102.64-103.05 | 3 | 2.8 × 10-4 | −0.75 (0.20) | [11] | ||
| C18:2IMF | 83.14-87.07 | 3 | 1.4 × 10-4 | 0.96 (0.29) | [11, 12] | |
| 103.89-112.25 | 4 | 1.8 × 10-4 | 0.89 (0.29) | [11, 12] | ||
| 122.39-125.33 | 7 | 1.6 × 10-4 | 0.97 (0.31) | [11, 12] | ||
| 137.22-141.52 | 23 | 4.2 × 10-5 | −1.03 (0.28) | [11, 12] | ||
| 4 | C16:0IMF | 96.10-97.84 | 6 | 6.0 × 10-4 | −0.72 (0.21) | [11, 13, 23] |
| C16:1(n-7)IMF | 54.27-59.91 | 7 | 2.6 × 10-5 | 0.21 (0.04) | [11, 23] | |
| 96.38-96.48 | 2 | 1.1 × 10-5 | 0.23 (0.05) | [11, 23] | ||
| 136.10-136.33 | 3 | 1.7 × 10-7 | 0.21 (0.03) | [11] | ||
| C18:2IMF | 13.60-13.89 | 2 | 5.0 × 10-5 | −0.99 (0.28) | [9, 10, 23, 24] | |
| 19.84-21.78 | 4 | 4.1 × 10-5 | 1.23 (0.32) | [9, 10, 23, 24] | ||
| 27.68-34.65 | 14 | 5.0 × 10-6 | −1.10 (0.26) | [9, 10, 23, 24] | ||
| 31.92-47.70 | 24 | 2.4 × 10-6 | −1.11 (0.25) | [9, 10, 23, 24] | ||
| 54.27-54.69 | 17 | 2.6 × 10-5 | −0.92 (0.25) | [9, 10, 23, 24] | ||
| 59.06-73.18 | 30 | 1.4 × 10-5 | −1.14 (0.29) | [9, 10, 23, 24] | ||
| 73.18-74.58 | 2 | 7.5 × 10-4 | 0.80 (0.28) | [9, 10, 23, 24] | ||
| 5 | C14:0IMF | 28.55-30.13 | 5 | 6.3 × 10-6 | 0.08 (0.02) | [11] |
| 8 | C16:0IMF | 90.73-92.44 | 5 | 2.1 × 10-4 | 0.55 (0.14) | [9, 11, 12, 25] |
| 99.33-99.49 | 3 | 9.7 × 10-6 | 0.57 (0.12) | [9, 11, 12, 25] | ||
| 110.90-111.01 | 2 | 1.4 × 10-5 | 0.65 (0.14) | [9, 11, 12, 25] | ||
| 114.21-121.04 | 17 | 7.7 × 10-9 | −0.74 (0.12) | [9, 11, 12, 25] | ||
| 123.81-125.08 | 2 | 1.7 × 10-4 | 0.53 (0.14) | [9, 11, 12, 25] | ||
| 130.63-134.57 | 3 | 7.7 × 10-6 | 0.60 (0.13) | [9, 11, 12, 25] | ||
| C16:1(n-7)IMF | 99.33-99.49 | 3 | 3.4 × 10-7 | 0.21 (0.04) | [9, 11, 25] | |
| 114.24-122.29 | 18 | 4.9 × 10-9 | −0.23 (0.04) | [9, 11, 25] | ||
| 11 | C18:1(n-9)IMF | 4.65-4.81 | 3 | 2.0 × 10-5 | 1.69 (0.43) | [11] |
| C18:2IMF | 4.65-5.10 | 4 | 1.2 × 10-4 | −1.25 (0.36) | [11] | |
| 13 | C16:0IMF | 109.42-113.53 | 7 | 4.8 × 10-5 | −0.54 (0.14) | New |
| C18:2IMF | 110.18-114.48 | 6 | 2.1 × 10-4 | −1.08 (0.34) | New | |
| 14 | C18:2IMF | 1.47-13.67 | 26 | 9.8 × 10-6 | 1.22 (0.31) | [11–13] |
| 51.55-53.07 | 7 | 3.8 × 10-4 | −0.96 (0.33) | [11–13] | ||
| 15 | C16:0IMF | 106.39-109.72 | 5 | 5.2 × 10-4 | −0.80 (0.23) | [13] |
| 122.99-124.17 | 5 | 2.1 × 10-5 | −0.60 (0.16) | [13] | ||
| 17 | C16:0IMF | 22.32-26.80 | 3 | 1.1 × 10-4 | −0.59 (0.15) | [11] |
P-value and additive effects of the most significant SNP in each interval; a (SE): additive effect (standard error); §Reference number of the previous studies identifying a QTL for the same trait in any fat tissue.