Table 3.
Rank correlations (ρ) and partial rank correlations (ρp) of the examined genomic properties with expression dissimilarities (measured by ExpD 1- r or ExpD Euc) of the adjacent paralogous genes of different orientations.
| Genomic properties a | ExpD 1-r | ExpD Euc | ||
|---|---|---|---|---|
| ρ ( P -value) b | ρ p ( P -value) b,c | ρ ( P -value) b | ρ p ( P -value) b,c | |
| Head-to-Head d | ||||
| d | 0.165 (0.072) | 0.106 (0.250) | 0.150 (0.109) | 0.036 (0.700) |
| #CTCF | 0.213 (0.020) | 0.173 (0.058) | 0.352 (<10-4) | 0.327 (<10-3) |
| ΔCpG O/E | -0.024 (0.794) | 0.001 (0.991) | -0.071 (0.443) | -0.054 (0.561) |
| Head-to-Tail d | ||||
| d | 0.005 (0.870) | -0.050 (0.110) | 0.089 (<10-2) | 0.016 (0.607) |
| #CTCF | 0.100 (<10-2) | 0.110 (<10-3) | 0.151 (<10-5) | 0.127 (<10-4) |
| ΔCpG O/E | 0.083 (<10-2) | 0.085 (<10-2) | 0.109 (<10-3) | 0.104 (<10-3) |
| Tail-to-Tail d | ||||
| d | 0.139 (0.110) | 0.105 (0.230) | 0.145 (0.096) | 0.046 (0.602) |
| #CTCF | 0.113 (0.195) | 0.061 (0.482) | 0.271 (<10-2) | 0.202 (0.019) |
| ΔCpG O/E | 0.050 (0.569) | 0.018 (0.0835) | 0.212 (0.014) | 0.153 (0.078) |
a "d", intergenic distance; "#CTCF", number of overlapping CTCF-binding sites; "ΔCpG O/E", difference in upstream DNA methylation.
b P values show the probabilities of the observations under the hypothesis of no correlation.
c Spearman's partial correlation coefficient ρp is computed by controlling for the other two genomic properties listed in a
d There were 120, 1003 and 133 head-to-head, head-to-tail and tail-to-tail adjacent paralogs, respectively.