Table 5.
Enriched/depleted GO terms at level 4 for genes with high #CTCF/d flanking regions
| Functional categories | Duplicate with 25% top #CTCF/d vs. rest of duplicates | Non-duplicates with 25% top #CTCF/d vs. rest of non-duplicates |
|---|---|---|
| GO terms a (↑ or ↓ b , P -value c ) | GO terms (↑ or ↓ b , P -value c ) | |
| Molecular functions | ||
|
DNA binding
(GO:0003677) (↑, P<0.05) |
transferase activity, transferring phosphorus-containing groups (GO:0016772) (↑, P<10-7) |
|
|
transcription factor binding
(GO:0008134) (↑, P<10-2) |
hydrolase activity, acting on acid anhydrides (GO:0016817) (↑, P<10-4) | |
|
SMAD binding
(GO:0046332) (↑, P<0.05) |
protein domain specific binding (GO:0019904) (↑, P<10-2) |
|
|
growth factor binding
(GO:0019838) (↑, P<0.05) |
substrate-specific transmembrane transporter activity (GO:0022891) (↑, P<10-4) | |
|
kinase inhibitor activity
(GO:0019210) (↑, P<0.05) |
cytoskeletal protein binding (GO:0008092) (↑, P<10-7) |
|
|
peptidase inhibitor activity
(GO:0030414) (↑, P<0.05) |
phospholipid binding (GO:0005543) (↑, P<10-2) |
|
|
protein kinase regulator activity
(GO:0019887) (↑, P<0.05) |
identical protein binding (GO:0042802) (↑, P<10-8) |
|
| transferase activity, transferring acyl groups (GO:0016746) (↑, P<0.05) | receptor binding (GO:0005102) (↑, P<10-9) |
|
| transferase activity, transferring glycosyl groups (GO:0016757) (↓, P<0.05) | heat shock protein binding (GO:0031072) (↑, P<0.05) |
|
| monooxygenase activity (GO:0004497) (↓, P<0.05) |
oxidoreductase activity, acting on peroxide as acceptor (GO:0016684) (↑, P<10-2) | |
| Cellular components | ||
| extracellular matrix (GO:0031012) (↑, P<10-6) |
extracellular matrix (GO:0031012) (↑, P<10-3) |
|
|
intracellular
(GO:0031012) (↑, P<0.05) |
extracelluar space (GO:0005615) (↑, P<10-8) |
|
| receptor complex (GO:0043235) (↑, P<0.05) | endomembrane system (GO:0012505) (↑, P<10-3) |
|
| membrane-bounded vesicle (GO:0031988) (↑, P<0.05) | ||
| cell surface (GO:0009986) (↑, P<10-4) |
||
| cell projection (GO:0042995) (↑, P<0.05) |
||
| midbody (GO:0030496) (↑, P<0.05) |
||
| Biological processes | ||
| response to organic substance (GO:0010033) (↑, P<0.05) |
response to organic substance (GO:0010033) (↑, P<10-5) |
|
|
regulation of metabolic process
(GO:0019222) (↑, P<10-3) |
lipid metabolic process (GO:0006629) (↑, P<10-6) |
|
|
regulation of catalytic activity
(GO:0050790) (↑, P<10-2) |
defense response (GO:0006952) (↑, P<10-3) |
|
|
regulation of cellular process
(GO:0050794) (↑, P<10-3) |
response to other organism (GO:0051707) (↑, P<0.05) |
|
| regulation of cellular component organization (GO:0051128) (↑, P<0.05) | carbohydrate metabolic process (GO:0005975) (↑, P<0.05) |
|
|
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
(GO:0006139) (↑, P<10-2) |
response to drug (GO:0042493) (↑, P<10-3) |
|
| macromolecule biosynthetic process (GO:0009059) (↑, P<10-3) | cell-cell signaling (GO:0007267) (↑, P<10-2) |
|
|
gene expression
(GO:0010467) (↑, P<10-2) |
cytoskeleton organization (GO:0007010) (↑, P<10-3) |
|
|
cellular biosynthetic process
(GO:0044249) (↑, P<10-4) |
regulation of developmental process (GO:0050793) (↑, P<10-4) | |
|
programmed cell death
(GO:0012501) (↑, P<10-2) |
regulation of immune system process (GO:0002682) (↑, P<10-4) | |
a Specifically enriched GO terms are highlighted in bold fonts
b The symbol ↑or ↓ represents the enrichment status of "enriched" or "depleted" of the GO term, respectively.
c P values were Bonferroni-corrected for multiple tests