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. 2014 Mar 15;8(5):4430–4439. doi: 10.1021/nn4063962

Figure 2.

Figure 2

TNFS aligns cell monolayers and spontaneously detaches cell sheets in response to temperature change. (a) DIC image of C2C12 myoblasts cultured on the TNFS and control at 37 °C 24 h after seeding. The TNFS aligns the cell monolayer. Scale bar, 100 μm. (b) Phase contrast image of C2C12 monolayers after incubation at 22 °C for 30 min undergoing spontaneous detachment on both the TNFS and control. Black arrows indicate detaching edge of cell sheet. Yellow arrows indicate TNFS nanopattern direction. Scale bar, 200 μm.