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Schematic representation of the modulation of POMC neurons and MC4R containing neurons by peripheral signals involved in the regulation of energy balance, glucose levels, and cardiovascular function
The figure also highlights the opposing actions of POMC neurons vs. AGRP/NPY neurons on MC4R activation, and an auto-potentiation/auto-stimulation loop on POMC neurons mediated by the MC4R. AGRP, agouti-related peptide; MC4R, melanocortin 4 receptors; NPY, neuropeptide Y.
