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. 2014 May;29(3):196–202. doi: 10.1152/physiol.00061.2013

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©2014 Int. Union Physiol. Sci./Am. Physiol. Soc.

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FIGURE 3. — Compilation of data demonstrating the impact of MC4R activation with the MC3/4 agonist MTII or the MC3/4 antagonist SHU-9119 on food intake

A: compilation of data demonstrating the impact of MC4R activation with the MC3/4 agonist MTII or the MC3/4 antagonist SHU-9119 on food intake in Sprague-Dawley (SD) rats. The average changes (Δ) in mean arterial pressure (B) and heart rate (C) in normotensive and hypertensive rats (SHR) during days 7 to 12 of treatment with MTII or SHU-9119. Image modified from Refs. 7, 26, 27 and used with permission.