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. 2013 Nov 23;14(1):824. doi: 10.1186/1471-2164-14-824

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© Chang et al.; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The distribution of transcriptional up-regulated, down-regulated and unchanged genes has SUMO binding within their promoter region before and after viral reactivation. (A and B) Genes transcriptionally up-regulated, down-regulated and unchanged after viral reactivation were plotted against SUMO-1 (A) or SUMO-2/3 (B) occupancy on the promoter region of control (0 hr; left panel) and KSHV reactivated (12 hr; right panel) BCBL-1 cells. (C to E) Genes transcriptionally up-regulated, down-regulated and unchanged after viral reactivation were plotted against SUMO-1 (left panel) and SUMO-2/3 (right panel) occupancy that was increased (C), decreased (D) or unchanged (E) on the promoter region during KSHV reactivation. Bars represent % of transcriptionally up-regulated, down-regulated and unchanged genes with SUMO occupancy that was normalized to total transcriptionally up-regulated, down-regulated and unchanged genes during viral reactivation, respectively.