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. 2013 Nov 23;14(1):824. doi: 10.1186/1471-2164-14-824

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© Chang et al.; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Genome-wide analysis of SUMO-1 and SUMO-2/3 binding region during KSHV reactivation. (A-C) Distance distribution of all SUMO-1 and SUMO-2/3 peaks. Distance to transcription start site (TSS) before (A) and after (B and C) K-Rta induction for viral reactivation. (D and E) Gene context of SUMO-1 (D) and SUMO-2/3 (E) binding sites during KSHV reactivation represented by peak density, after adjustment for the prevalence of gene context category in the genome. Promoter: TSS ± 500; Promoter pro. (Promoter proximal): TSS ± 2 Kb; 3′ end: TES ± 500; Upstream: -2 kb to −10 kb upstream of the TSS; Downstream: +2 kb to +10 kb downstream of the TES; Intergenic: ≥10 kb from any coding genes. TES: transcription end site.