Table 2.
Function of common elements obtained from the high temperature stress experiment and the low oxygen stress experiment
| Gene symbol | Gene product | Temperature effect | Metabolic function | Protein function |
|---|---|---|---|---|
| ADK | Adenosine kinase | Up | ATP/ITP metabolism | ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives |
| BTD | Biotinidase | Up | Biotin metabolism | Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation |
| CREB3L3 | cAMP responsive element binding protein 3-like 3 | Up | Transcription regulation | Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes |
| CYP1A | Cytochrome P450, family 1, subfamily A | Up | Monooxygenase activity | Oxidization of a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics |
| GSTA1 | Glutathione S-transferase alpha 1 | Up | Glutathione metabolic process | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles |
| KNG1 | Kininogen 1 | Up | Inflammatory response | Multiple function, high molecular weight kininogen (HMWK) involved in blood coagulation |
| RPL10 | Ribosomal protein L10 | Up | Translation | Component of the large 60S ribosomal subunit |
| RPL19 | Ribosomal protein L19 | Up | Translation | Component of the large 60S ribosomal subunit |
| RPL3 | Ribosomal protein L3 | Up | Translation | Component of the large 60S ribosomal subunit |
| TSTD1 | Thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 | Up | Tumorigenesis? | Highly expressed in liver, possible role in tumorigenesis |
| BTF3 | Basic transcription factor 3 | Down | Regulation of transcription | Required for the initiation of transcription |
| CPN1 | Carboxypeptidase N, polypeptide 1 | Down | Proteolysis | Protects the body from potent vasoactive and inflammatory peptides released into the circulation |
| EIF3C/EIF3CL | Eukaryotic translation initiation factor 3, subunit C/-like | Down | Initiation of protein synthesis | Component of the eukaryotic translation initiation factor 3 |
| H2AFV | H2A histone family, member V | Down | Nucleosome assembly | Play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability |
| HTRA1 | High-temperature requirement A serine peptidase 1 | Down | Regulation of cell growth/proteolysis | Serine protease with a variety of targets. Regulates the availability of insulin-like growth factors (IGFs) |
| NDUFS1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75 kDa (NADH-coenzyme Q reductase) | Down | Mitochondrial electron transport, NADH to ubiquinone | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase |
| PABPC1 | Poly(A) binding protein, cytoplasmic 1 | Down | mRNA polyadenylation | May be involved in cytoplasmic regulatory processes of mRNA metabolism |
| PNP | Purine nucleoside phosphorylase | Down | Nucleobase-containing compound metabolic process | Catalyze phosphorolysis of purine nucleosides |
| PSAP | Prosaposin | Down | Lipid metabolic process | Catabolism of glycosphingolipids with short oligosaccharide groups |