Table 4.
Regional distribution of filamentous PrP in a brain with A117V mutation (Case #17): semiquantitative scoring of white matter PrP filaments
| Case #17: areas analysed | Density of filamentous PrP in white matter tracts in the region |
|---|---|
| Anterior frontal F1-F2 | +++ |
| Posterior frontal Superior frontal gyrus and pre motor cortex | ++ |
| Temporal T1-T2 | +++ |
| Temporal T2-T3 | +++ |
| Tip of temporal lobe | +++ |
| Parietal | ++ |
| Occipital | ++ |
| Anterior cingulate | +++ |
| Hippocampus | +++ |
| Amygdala | +++ |
| Basal ganglia, ant. | +++ |
| Basal ganglia, mid. | +++ |
| Basal ganglia, post | ++ |
| Thalamus with subthalamic nucleus | + |
| Upper midbrain | +/++ |
| Lower midbrain | + |
| Pons | + |
| Lower medulla | n.a. |
| Cerebellum Vermis | + |
| Cerebellum with dentate | - |
| Cerebellum hemisphere | (+) |
The graphical representation is shown in Figure 7.