Proportion of participants with substance dependence across follow-ups. Sample size differs slightly by types of substance due to missing data. Overall sample sizes were Persistent ADHD, FU1 n = 79, FU2 n = 79, FU3 n = 69; Childhood-Limited ADHD, FU1 n = 71, FU2 n = 70, FU3 n = 52; and Normal Control, FU1 n = 69, FU2 n = 69, FU3 n = 62.