Table 2.
Descriptive statistics and treatment effects at 1 year follow-up
| Primary outcome measures | Baseline (n = 159) | Follow-up 1 (n = 146) | Follow-up 2 (n = 144) | Follow-up 3 (n = 131) |
|---|---|---|---|---|
|
Global fatigue severity (GFS) subscale of the FAI(potential range 1 to 7, high scores indicate more fatigue) | ||||
| FACETS mean (SD) |
5.60 (0.98) |
5.48 (0.92) |
5.26 (1.03) |
5.32 (1.00) |
| CLP mean (SD) |
5.61 (1.09) |
5.55 (1.17) |
5.66 (0.93) |
5.70 (1.01) |
| Mean difference in change from baseline [95% CI] |
- |
−0.03 (−0.33 to 0.28) |
−0.36 (−0.63 to −0.08) |
−0.30 (−0.61 to 0.01) |
| p value |
- |
0.86 |
0.01 |
0.06 |
| Std effect size |
- |
−0.03 |
−0.35 |
−0.29 |
|
Multiple Sclerosis Impact Scale-29 (MSIS-29)(potential range 0 to 100, high scores indicate more impact) | ||||
| FACETS mean (SD) |
49.6 (19.1) |
47.3 (18.2) |
44.9 (19.2) |
46.2 (19.1) |
| CLP mean (SD) |
43.9 (17.6) |
42.2 (18.4) |
43.0 (17.3) |
47.2 (17.4) |
| Mean difference in change from baseline [95% CI] |
- |
1.44 (−2.36 to 5.24) |
−1.56 (−6.45 to 3.34) |
−4.34 (−8.61 to −0.08) |
| p value |
- |
0.46 |
0.53 |
0.046 |
| Std effect size |
- |
0.08 |
−0.08 |
−0.24 |
|
MS Fatigue Self-Efficacy scale (MS-FSE)(potential range 10 to 100, high scores indicate more certainty in controlling fatigue | ||||
| FACETS mean (SD) |
45 (17) |
57 (17) |
56 (19) |
56 (16) |
| CLP mean (SD) |
49 (16) |
50 (17) |
53 (17) |
52 (17) |
| Mean difference in change from baseline [95% CI] |
- |
9 (4 to 14) |
6 (0 to 12) |
6 (−1 to 12) |
| p value |
- |
0.001 |
0.048 |
0.09 |
| Std effect size |
- |
0.54 |
0.36 |
0.34 |
|
Statistically significant secondary outcome measures | ||||
|
Vitality subscale of the SF-36(potential range 0 to 100, high scores indicate higher quality of life) | ||||
| FACETS mean (SD) |
32.0 (16.8) |
35.6 (19.4) |
37.4 (20.3) |
37.70 (18.75) |
| CLP mean (SD) |
35.1 (19.7) |
33.4 (16.8) |
34.4 (17.30 |
32.43 (17.69) |
| Mean difference in change from baseline [95% CI] |
- |
4.42 (−1.22 to 10.06) |
6.38 (0.45 to 12.32) |
6.64 (0.84 to 12.44) |
| p value |
- |
0.12 |
0.04 |
0.03 |
| Std effect size |
- |
0.24 |
0.35 |
0.37 |
|
Multiple Sclerosis Impact Scale-29 (MSIS-29) - Physical subscale(potential range 0 to100, high scores indicate more impact) | ||||
| FACETS mean (SD) |
51.4 (21.4) |
48.8 (19.7) |
47.0 (21.3) |
47.4 (21.0) |
| CLP mean (SD) |
46.6 (20.3) |
44.9 (20.5) |
46.5 (19.8) |
50.5 (20.1) |
| Mean difference in change from baseline [95% CI] |
- |
1.39 (−2.87 to 5.65) |
−0.81 (−5.91 to 4.28) |
−4.74 (−9.40 to −0.08) |
| p value |
- |
0.52 |
0.75 |
0.046 |
| Std effect size | - | 0.07 | −0.04 | −0.23 |