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Tissue distribution of platinum in different treatment groups as determined ICP- MS. (A) Mice were sacrificed at day 14 of the treatment with (CDDP+PTX)/cl-micelles or CDDP/cl-micelles or free CDDP. (B) Significant reduction in the Pt levels in various organs of mice treated with (CDDP+PTX)/cl-micelles was confirmed by comparing Pt levels at day 14 and day 45. Values indicated are means ± SEM (n = 3), * P<0.05.
