Table 3.
Physicochemical characteristics of cl-micelles before and after drug loading.
| Sample | Deff (nm) | PDI | ζ-potential (mV) | LC (w/w%)b |
|---|---|---|---|---|
| cl-micelles | 90 ± 1.2 | 0.14 | −20.0 ± 1.2 | - |
| PTX/cl-micelles | 105 ± 2.8 | 0.23 | −19.1 ± 1.5 | 8.4 |
| CDDP/cl-micelles | 71 ± 3.3 | 0.19 | −3.7 ± 1.0 | 22.4 |
| (CDDP+PTX)/cl-micelles | 76 ± 4.0 | 0.24 | −5.7 ± 0.47 | 24.8c |
a
Effective diameter (Deff), polydispersity index (PDI) and ζ-potential were determined in water (pH 6.5).
b
Pt and PTX content were deternined by ICP-MS and HPLC, respectively. Loading capacity (LC) is expressed as mass of incorporated drug per mass of drug loaded cl-micelles (w/w).
c
Total LC for combination of CDDP (15.4%) and PTX (9.4%).
Data are expressed as mean ± SD (n = 3).