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. 2014 Apr 26;10(5):511–519. doi: 10.7150/ijbs.8631

Figure 2.

Figure 2

Figure 2

Figure 2

Figure 2

Changes in [Ca2+]i, [PKC]A, [ATP]e and [IP3] in a single isolated mast cell model, as functions of time (t). Solid line represents simulation results after exposure to an initiating mechanical stimuli during time t=0-60s, dash line represents the stable state without stimuli. (a) immediately [Ca2+]i rise. (b) [Ca2+]i rise activates PKC ( [PKC]A rise). (c) ATP release after [PKC]A accumulate over threshold value. (d) [IP3] rise quickly when ATP release from mast cell and act on purinergic receptors of the cell.