Table 1.
Changes in PPBG over time and animal data at 15 weeks of age.
| Parameters | LETO + vehicle | OLETF + vehicle | OLETF + olmesartan | OLETF + HRH |
|---|---|---|---|---|
| (N = 4) | (N = 4) | (N = 4) | (N = 4) | |
| PPBG, mg/dl | ||||
| 5 weeks | 120.8 ± 8.3 | 130.8 ± 9.7 | 126.8 ± 8.0 | 130.8 ± 9.1 |
| 7 weeks | 97.0 ± 1.7 | 151.3 ± 12.2 | 137.5 ± 12.7 | 95.5 ± 28.5 |
| 9 weeks | 92.8 ± 2.1 | 125.0 ± 7.9 | 130.8 ± 8.4 | 142.3 ± 16.9 |
| 11 weeks | 92.5 ± 4.1 | 155.3 ± 23.1 * | 139.3 ± 17.4 # | 160.3 ± 14.8 |
| BW, g | 396.3 ± 7.5 | 486.5 ± 5.8 ** | 453.5 ± 11.1 ## | 464.0 ± 8.2 |
| UAlb, mg/g Cr | 38.8 ± 3.7 | 250.5 ± 68.7 ** | 23.1 ± 5.3 ## | 180.4 ± 13.6 |
| Angiotensin II in the kidney, fmol/g | 71.6 ± 17.8 | 171.6 ± 79.4 * | 23.0 ± 4.2 ## | 155.4 ± 19.6 |
| SBP, mmHg | 128.0 ± 5.5 | 157.3 ± 1.4 ** | 113.3 ± 3.7 ## | 112.8 ± 3.7 ## |
| Cr, mg/dl | 0.61 ± 0.04 | 0.45 ± 0.05 | 0.56 ± 0.07 | 0.46 ± 0.07 |
| TG, mg/dl | 66.0 ± 4.1 | 363.5 ± 45.9 ** | 154.8 ± 10.9 ## | 238.5 ± 25.6 # |
| Adiponectin, µg/ml | 2.6 ± 0.5 | 4.0 ± 0.6 | 5.0 ± 1.0 | 2.4 ± 0.9 |
PPBG, postprandial blood glucose; BW, body weight; SBP, systolic blood pressure; UAlb, urinary albumin excretion; Cr, creatinine; TG, triglyceride. * P < 0.05 vs. LETO + vehicle, ** P < 0.01 vs. LETO + vehicle, # P < 0.05 vs. OLETF + vehicle, and ## P < 0.01 vs. OLETF + vehicle.